PIK3CA-mutations in breast cancer.

Kristin ReinhardtKathrin StückrathCarolin HartungSandy KaufholdChristoph UleerVolker HanfTillmann LantzschSusanne PeschelJutta JohnMarleen PöhlerMarcus BauerFriedrich Karl BürrigEdith WeigertJörg BuchmannEva Johanna KantelhardtChristoph ThomssenMartina Vetter

Published in: Breast cancer research and treatment (2022)

This cohort study speficies the overall mutation rate of PIK3CA in early breast cancer. The impact of PIK3CA-mutations on RFI and OS was heterogeneous. Our results suggest that estrogen deprivation failes to be active in case of PIK3CA-mutation.

Keyphrases

early breast cancer
protein kinase