An imbalance in the T-helper phenotypes displayed by senescent CD4+CD28null T cells is associated with erosive arthritis (rhupus syndrome) in systemic lupus erythematosus.
A C Lozada-NavarroD Castillo-MartínezM Moreno-RamírezG Acosta-PeñaA PáezF MassóR Márquez-VelascoLuis M Amezcua GuerraPublished in: Lupus (2018)
In patients with rhupus, senescent CD4+CD28null cells are preferentially polarized to a Th1 phenotype, whereas this is partial towards Th2 in lupus patients with a nonerosive arthritis pattern.