An imbalance in the T-helper phenotypes displayed by senescent CD4+CD28null T cells is associated with erosive arthritis (rhupus syndrome) in systemic lupus erythematosus.

A C Lozada-NavarroD Castillo-MartínezM Moreno-RamírezG Acosta-PeñaA PáezF MassóR Márquez-VelascoLuis M Amezcua Guerra

Published in: Lupus (2018)

In patients with rhupus, senescent CD4+CD28null cells are preferentially polarized to a Th1 phenotype, whereas this is partial towards Th2 in lupus patients with a nonerosive arthritis pattern.

Keyphrases

rheumatoid arthritis
induced apoptosis
systemic lupus erythematosus
disease activity
cell cycle arrest
regulatory t cells
dendritic cells
case report
endoplasmic reticulum stress
signaling pathway
cell death
oxidative stress
cell proliferation