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Progranulin autoantibodies in systemic sclerosis and autoimmune connective tissue disorders: A preliminary study.

Philipp KlemmGunter AssmannKlaus-Dieter PreussNatalie FadleEvi RegitzThierry MartinMichael PfreundschuhLorenz Thurner
Published in: Immunity, inflammation and disease (2019)
Progranulin antibodies are frequently present in patients with systemic sclerosis and other autoimmune connective tissue disorders. Despite the lack of specificity for a given autoimmune disease, progranulin antibodies might not only indicate a potential subtype but also play a pathogenic role in patients with autoimmune connective disorders. Given the important role of TNF-α in inflammatory processes in autoimmune connective tissue disorders, progranulin antibodies might support the proinflammatory environment by neutralizing the TNF blocker progranulin.
Keyphrases
  • systemic sclerosis
  • interstitial lung disease
  • multiple sclerosis
  • rheumatoid arthritis
  • drug induced
  • systemic lupus erythematosus
  • oxidative stress
  • zika virus
  • dengue virus