Organic Cation Transporter I and Na+ /taurocholate Co-Transporting Polypeptide are Involved in Retrorsine- and Senecionine-Induced Hepatotoxicity in HepaRG cells.

Anne-Margarethe EngeFlorian KaltnerChristoph GottschalkAngelina KinMichael KirstgenJoachim GeyerAnja TheseHelen HammerOliver PötzAlbert BraeuningStefanie Hessel-Pras

Published in: Molecular nutrition & food research (2021)

Our results confirm previous findings of active transport mechanisms of PAs into hepatocytes and highlight the importance of toxicokinetic studies for the risk assessment of PAs.

Keyphrases

risk assessment
drug induced
liver injury
induced apoptosis
cell cycle arrest
high glucose
heavy metals
human health
endoplasmic reticulum stress
signaling pathway
cell death
endothelial cells
water soluble
cell proliferation