Ischemic Stroke Thrombus Perviousness Is Associated with Distinguishable Proteomic Features and Susceptibility to ADAMTS13-Augmented Thrombolysis.
Derrek SchartzSajal Medha K AkkipeddiRedi RahmaniNathaniel R EllensClifton HoukGurkirat Singh KohliLogan WorleyKevin WelleTarun BhallaThomas K MattinglyCraig MorrellMatthew T BenderPublished in: AJNR. American journal of neuroradiology (2023)
Thrombus perviousness is associated with complex proteomic features, including differential abundance of platelet-related proteins in highly permeable clots with monocyte/macrophage depletion. This association may help to explain why highly pervious thrombi were also found more susceptible to ADAMTS13-augmented thrombolysis.