GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca2+ signalling in a GABA-independent manner.

Shu-Heng JiangLi-Li ZhuMan ZhangRong-Kun LiQin YangJiang-Yu YanCe ZhangJian-Yu YangFang-Yuan DongMiao DaiLi-Peng HuJun LiQing LiYa-Hui WangXiao-Mei YangYan-Li ZhangHui-Zhen NieLei ZhuXue-Li ZhangGuang-Ang TianXiao-Xin ZhangXiao-Yan CaoLing-Ye TaoShan HuangYong-Sheng JiangRong HuaKathy Qian LuoJian-Ren GuYong-Wei SunShangwei HouZhi-Gang Zhang

Published in: Gut (2019)

Overexpressed GABRP exhibits an immunomodulatory role in PDAC in a neurotransmitter-independent manner. Targeting GABRP or its interaction partner KCNN4 may be an effective therapeutic strategy for PDAC.

Keyphrases

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