Electronegative low-density lipoprotein of patients with metabolic syndrome induces pathogenesis of aorta through disruption of the stimulated by retinoic acid 6 cascade.

Chao-Hung ChenLiang-Yin KeHua-Chen ChanChih-Sheng ChuAn-Sheng LeeKun-Der LinMei-Yueh LeePi-Jung HsiaoChu-Huang ChenShyi-Jang Shin

Published in: Journal of diabetes investigation (2019)

This study shows that L5 from MetS patients induces atherogenic markers by disrupting STRA6 signaling. Suppression of STRA6 might be one novel pathogenesis of aorta in patients with MetS.

Keyphrases

low density lipoprotein
metabolic syndrome
end stage renal disease
aortic valve
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
insulin resistance
type diabetes
uric acid
patient reported outcomes
skeletal muscle
pulmonary hypertension