Communication of CD8+ T cells with mononuclear phagocytes in multiple sclerosis.

Matea Konjevic SabolekKathrin HeldEduardo BeltránAnna G NiedlEdgar MeinlReinhard HohlfeldHans LassmannKlaus Dornmair

Published in: Annals of clinical and translational neurology (2019)

Because CD163 and CD11b are specifically expressed in MPs, our findings suggest that CD8+ T cells communicate with local MPs. Although it is still unclear if these interactions lead to killing of the communication partners by CD8+ T cells, our data underline that CD8+ T cells play an active role in the pathogenesis of MS.

Keyphrases

multiple sclerosis
electronic health record
white matter
nk cells
ms ms
peripheral blood
big data
data analysis
human immunodeficiency virus
deep learning