Kinase Insert Domain Receptor Q472H Pathogenic Germline Variant Impacts Melanoma Tumor Growth and Patient Treatment Outcomes.

Milad IbrahimIrineu Illa-BochacaFaisal Fa'ak Kelsey R MonsonRobert FergusonChen LyuEleazar Vega-Saenz de MieraPaul JohannetMargaret ChouJustin MastroianniFarbod DarvishianTomas KirchhoffJudy ZhongMichelle KrogsgaardIman Osman

Published in: Cancers (2023)

Our data demonstrate a role of germline KDR-Var in modulating melanoma behavior, including response to treatment. Our data also suggest that anti-angiogenic therapy might be beneficial in patients harboring this genotype, which needs to be tested in clinical trials.

Keyphrases

clinical trial
end stage renal disease
electronic health record
chronic kidney disease
newly diagnosed
ejection fraction
dna repair
big data
signaling pathway
stem cells
case report
data analysis
protein kinase
mesenchymal stem cells
tyrosine kinase
open label
basal cell carcinoma
cell therapy
study protocol