Small molecule profiling to define synergistic EGFR inhibitor combinations in head and neck squamous cell carcinoma.
Nicole L MichmerhuizenMegan L LudwigAndrew C BirkelandSai NimmagaddaJingyi ZhaiJiayu WangBrittany M JewellDylan GenouwLindsay RemerDaniel KimSusan K FoltinApurva BhangaleAditi KulkarniCarol R BradfordPaul L SwiecickiThomas E CareyHui JiangJohn Chad BrennerPublished in: Head & neck (2022)
Conceptually, our data identify novel synergistic combinations that warrant evaluation in future studies, and suggest that some combinations, although highly synergistic, will require parallel companion diagnostic development to be effectively advanced in patients.
Keyphrases
- small molecule
- end stage renal disease
- cancer therapy
- small cell lung cancer
- newly diagnosed
- ejection fraction
- chronic kidney disease
- epidermal growth factor receptor
- peritoneal dialysis
- electronic health record
- tyrosine kinase
- protein protein
- drug delivery
- big data
- patient reported outcomes
- current status
- deep learning
- patient reported
- data analysis