Morphologic patterns observed in prostate biopsy cases with discrepant grade group and molecular risk classification.
Nancy Y GreenlandMatthew R CooperbergPeter R CarrollJanet E CowanJeffry P SimkoBradley A StohrEmily ChanPublished in: The Prostate (2024)
In GG1-2 high Decipher risk cases, difficult to grade patterns were frequently seen in the absence of other known high risk morphologic features; whether these constitute true high risk cases requires further study. In the GG ≥ 3 low Decipher risk cases, aggressive histologic patterns such as large cribriform and IDC were observed in half (50%) of cases; therefore, the molecular classifier may not capture all high risk histologic patterns.