Rare genetic variants in interleukin-37 link this anti-inflammatory cytokine to the pathogenesis and treatment of gout.

Viola KlückRosanne C van DeurenGiulio CavalliAmara ShaukatPeer ArtsMaartje C CleophasTania O CrișanAnne-Kathrin TauschePhilip RichesNicola DalbethLisa K StampJennie Harré HindmarshTim L Th A JansenMatthijs JanssenMarloes SteehouwerStefan LelieveldMaartje van de VorstChristian GilissenLorenzo DagnaFrank L Van de VeerdonkElan Z EisenmesserSooHyun KimTony R MerrimanAlexander HoischenMihai G NeteaCharles A DinarelloLeo A B Joosten

Published in: Annals of the rheumatic diseases (2020)

Here, we provide genetic as well as mechanistic evidence for the role of IL-37 in the pathogenesis of gout, and highlight the therapeutic potential of recombinant IL-37 for the treatment of gouty arthritis.

Keyphrases

uric acid
rheumatoid arthritis
gene expression
genome wide
metabolic syndrome
combination therapy
copy number
replacement therapy