Retinal Glial Cells in Von Hippel-Lindau Disease: A Novel Approach in the Pathophysiology of Retinal Hemangioblastoma.
Elisabetta PilottoGiulia MidenaTommaso TorresinGilda De MojàMaria Laura BacelleAlfonso Massimiliano FerraraStefania ZovatoEdoardo MidenaPublished in: Cancers (2021)
The OCT analysis, which detects and allows to quantify the biomarkers of retinal microglia (HRF) and macroglia (pRNFL, mRNFL and GCL), showed a different behavior of these two retinal glial cells populations in VHL patients, related to the presence or absence of peripheral RH. These data allow to hypothesize a novel pathophysiologic pathway of retinal hemangioblastoma in VHL disease.
Keyphrases
- optical coherence tomography
- diabetic retinopathy
- optic nerve
- induced apoptosis
- cell cycle arrest
- end stage renal disease
- neuropathic pain
- ejection fraction
- chronic kidney disease
- electronic health record
- inflammatory response
- signaling pathway
- endoplasmic reticulum stress
- spinal cord
- prognostic factors
- big data
- patient reported
- deep learning