Effect of Pathway-specific Polygenic Risk Scores for Alzheimer's Disease (AD) on Rate of Change in Cognitive Function and AD-related Biomarkers among Asymptomatic Individuals.

Yuexuan XuEva VasiljevicYuetiva K DemingErin M JonaitisRebecca L KoscikCarol A Van HulleQiongshi LuMargherita CarboniGwendlyn KollmorgenNorbert WildCynthia M CarlssonSterling C JohnsonHenrik ZetterbergKaj BlennowCorinne D Engelman

Published in: medRxiv : the preprint server for health sciences (2023)

, the p-PRSs can predict age-dependent changes in beta-amyloid, tau, and cognition. Once validated, they could be used to identify individuals with an elevated genetic risk of accumulating beta-amyloid and tau, long before the onset of clinical symptoms.

Keyphrases

cerebrospinal fluid
cognitive decline
white matter
copy number
dna methylation