SPG21, a potential oncogene targeted by miR-128-3p, amplifies HBx-induced carcinogenesis and chemoresistance via activation of TRPM7-mediated JNK pathway in hepatocellular carcinoma.

Ping ZhouWei YaoLijuan LiuQiujin YanXiaobei ChenXiaocui WeiShuang DingZhao LvFan Zhu

Published in: Cellular oncology (Dordrecht) (2024)

/JNK signaling pathway. This insight suggested that SPG21 could be recognized as a potential oncogene, offering a novel perspective on its role as a prognostic factor and a therapeutic target in the context of HCC.

Keyphrases

signaling pathway
prognostic factors
induced apoptosis
cell death
pi k akt
epithelial mesenchymal transition
hepatitis b virus
high glucose
diabetic rats
oxidative stress
drug delivery