Distinct transcriptional signatures in purified circulating immune cells drive heterogeneity in disease location in IBD.

Bram Verstockt Sare VerstocktJonathan CremerJoão SabinoMarc FerranteSeverine VermeirePadhmanand Sudhakar

Published in: BMJ open gastroenterology (2023)

Transcriptomic profiling of circulating CD4 T-cells in patients with IBD demonstrated marked molecular differences between the IBD-spectrum extremities (UC and predominantly ileal CD, sandwiching colonic CD), which could help in prioritising particular drug targets for IBD subtypes.

Keyphrases

ulcerative colitis
single cell
rna seq
transcription factor
dna methylation
oxidative stress
soft tissue
adverse drug
drug induced
heat stress