CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms.
Margaretha A SkowronMarieke VermeulenAnna WinkelhausenTeresa K BeckerFelix BremmerPatrick PetzschStefan SchönbergerGabriele CalaminusKarl KöhrerPeter AlbersDaniel NettersheimPublished in: British journal of cancer (2020)
Our study highlights PaRi as therapeutic options for cisplatin-resistant and -sensitive paediatric and adult GCTs.