Drug-induced cardiomyopathy: Characterization of a rat model by [18F]FDG/PET and [99mTc]MIBI/SPECT.

Hailey HousonAndria HedrickVibhudutta Awasthi

Published in: Animal models and experimental medicine (2020)

We conclude that [18F]FDG is a more sensitive radiotracer than [99mTc]MIBI for imaging of drug-induced cardiomyopathy. We theorize that isoproterenol-induced cardiomyopathy impacts cellular metabolism more than perfusion, which results in more substantial changes in [18F]FDG uptake than in [99mTc]MIBI accumulation in cardiac tissue.

Keyphrases

drug induced
pet ct
pet imaging
liver injury
positron emission tomography
heart failure
computed tomography
high resolution
adverse drug
left ventricular
contrast enhanced
high glucose
photodynamic therapy
oxidative stress
atrial fibrillation