Whole blood transcriptional profiling reveals highly deregulated atherosclerosis genes in Philadelphia-chromosome negative myeloproliferative neoplasms.
Vibe SkovMads ThomassenLasse KjaerMorten Kranker LarsenTrine A KnudsenChristina EllervikTorben A KruseHans Carl Carl HasselbalchPublished in: European journal of haematology (2023)
We have for the first time shown massive deregulation of atherosclerosis genes in MPNs, likely reflecting the inflammatory state in MPNs in association with in vivo activation of leukocytes, platelets, and endothelial cells being deeply involved in the atherosclerotic process.
Keyphrases
- endothelial cells
- genome wide
- cardiovascular disease
- acute lymphoblastic leukemia
- bioinformatics analysis
- genome wide identification
- gene expression
- oxidative stress
- copy number
- single cell
- peripheral blood
- dna methylation
- genome wide analysis
- high glucose
- type diabetes
- vascular endothelial growth factor
- chronic myeloid leukemia
- heat shock
- heat shock protein