Angiotensin-Converting Enzyme Inhibitors Versus Angiotensin II Receptor Blockers in Acute Coronary Syndrome and Preserved Ventricular Ejection Fraction.
María Cespón FernándezSergio Raposeiras-RoubínEmad Abu-AssiIsabel Muñoz PousaBerenice Caneiro QueijaRafael José Cobas PazPablo Domínguez ErquiciaLuis Manuel Domínguez RodríguezElena López RodríguezMaría Castiñeira BustoSaleta Fernández BarbeiraAndrés Íñiguez RomoPublished in: Angiology (2020)
Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin II receptor blockers (ARB) showed comparable survival results in patients with heart failure (HF) and reduced left ventricular ejection fraction (LVEF). However, there is lack of evidence of the comparative effectiveness in preserved LVEF patients after an acute coronary syndrome (ACS). The aim of this study was to evaluate whether the selection between ACEi and ARB in preserved LVEF after an ACS confers a prognostic benefit, based on real life results. We analyzed a cohort of 3006 contemporary patients with LVEF ≥40% after an ACS. A propensity score matching and Cox regression analysis were performed to assess the association between treatment and events (death, acute myocardial infarction [AMI], HF, and combined event) for a mean follow-up of 3.6 ± 2.1 years. We found no significant differences between ACEi/ARB for all-cause mortality (hazard ratio [HR] for ARB: 0.95, 95% CI: 0.70-1.29), AMI (HR for ARB: 1.34, 95% CI: 0.95-1.89), HF (HR for ARB: 1.11, 95% CI: 0.85-1.45), or combined end point (death, AMI and HF: HR for ARB: 1.14, 95% CI: 0.92-1.40). In conclusion, there are no prognostic differences between the use of ACEi and ARB in patients with LVEF ≥40% after ACS. Further prospective studies are needed to confirm our results.
Keyphrases
- angiotensin converting enzyme
- angiotensin ii
- acute coronary syndrome
- ejection fraction
- acute myocardial infarction
- percutaneous coronary intervention
- aortic stenosis
- left ventricular
- vascular smooth muscle cells
- antiplatelet therapy
- heart failure
- end stage renal disease
- coronary artery disease
- atrial fibrillation
- newly diagnosed
- hypertrophic cardiomyopathy
- binding protein
- free survival
- replacement therapy
- mitral valve
- aortic valve
- peritoneal dialysis
- catheter ablation
- left atrial
- case control