Correlation of genomic alterations between tumor tissue and circulating tumor DNA by next-generation sequencing.

Ya-Sian ChangHsin-Yuan FangYao-Ching HungTao-Wei KeChieh-Min ChangTing-Yuan LiuYu-Chia ChenDy-San ChaoHsi-Yuan HuangJan-Gowth Chang

Published in: Journal of cancer research and clinical oncology (2018)

This study indicates that tissue NGS and ctDNA NGS are complementary rather than exclusive approaches; these data support the idea that ctDNA is a promising tool to interrogate cancer genetics.

Keyphrases

circulating tumor
cell free
circulating tumor cells
papillary thyroid
copy number
big data
gene expression
dna methylation
childhood cancer
single molecule