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Effects of colchicine on lipolysis and adipose tissue inflammation in adults with obesity and metabolic syndrome.

Jordan A LevineZahra Sarrafan-ChaharsoughiTushar P PatelSheila M BradyK Karthik ChivukulaEmily MillerJung Min HanVipul PeriwalAnna WolskaAlan T RemaleyPradeep K DagurAngelique BiancottoAshley L BabyakGiovanna FantoniJack A YanovskiAndrew Paul Demidowich
Published in: Obesity (Silver Spring, Md.) (2022)
In adults with obesity and MetS, colchicine appears to improve insulin regulation of lipolysis and reduce markers of systemic inflammation independent of an effect on local leukocyte distributions in SAT. Further studies are needed to better understand the mechanisms by which colchicine affects adipose tissue metabolic pathways in adults with obesity and MetS.
Keyphrases
  • adipose tissue
  • insulin resistance
  • metabolic syndrome
  • type diabetes
  • high fat diet induced
  • high fat diet
  • weight loss
  • weight gain
  • glycemic control
  • oxidative stress
  • uric acid
  • physical activity