IGF-1 enhances BMSC viability, migration, and anti-apoptosis in myocardial infarction via secreted frizzled-related protein 2 pathway.

Mingzhuo LinXinyue LiuHaoxiao ZhengXiaohui HuangYu WuAnqing HuangHailan ZhuYunzhao HuWeiyi MaiYuli Huang

Published in: Stem cell research & therapy (2020)

These results suggest that in BMSCs overexpressing IGF-1, SFRP2 is an important mediator for the enhancement of stem cell viability via activating, rather than antagonizing, the Wnt/β-catenin pathway.

Keyphrases

pi k akt
cell cycle arrest
signaling pathway
binding protein
growth hormone
cell proliferation
oxidative stress
endoplasmic reticulum stress
stem cells
heart failure
left ventricular
cell death