Dihydromyricetin Modulates Nrf2 and NF-κB Crosstalk to Alleviate Methotrexate-Induced Lung Toxicity.
Asmaa I MatoukEman M AwadNashwa Fathy Gamal El-TahawyAzza A K El-SheikhAliaa AnterPublished in: Pharmaceuticals (Basel, Switzerland) (2023)
This study identified DHM as a promising therapeutic target against MTX-induced pneumonitis via activation of Nrf2 antioxidant signaling while suppressing the NF-κB mediated inflammatory pathways.