Ovarian cancer G protein-coupled receptor 1 inhibits A549 cells migration through casein kinase 2α intronless gene and neutral endopeptidase.

Adhikarimayum Lakhikumar SharmaPuyam Milan MeiteiTakhellambam Chanu MachathoibiNaorem Tarundas SinghThiyam Ramsing SinghLisam Shanjukumar Singh

Published in: BMC cancer (2022)

In the current study, we report for the first time the OGR1-induced regulation of CSNK2A3, CK2αP, and NEP in A549 cancer cells. Our study also decoded the downstream cellular proteins of OGR1 as well as the molecular mechanism involved in OGR1-induced inhibition of A549 cell migration. The findings of this research suggest the potential therapeutic targets to inhibit lung cancer progression.

Keyphrases

cell migration
high glucose
diabetic rats
induced apoptosis
drug induced
cell proliferation
climate change
endoplasmic reticulum stress