Sex-Specific Regulation of Interferon-γ Cytotoxicity in Mouse Liver by Autophagy.

Yang ShenFrancesca CingolaniShoaib Ahmad MalikJing WenYunshan LiuMark J Czaja

Published in: Hepatology (Baltimore, Md.) (2021)

Decreased hepatocyte autophagy sensitizes mice to IFNγ-induced liver injury and inflammation through overactivation of STAT1 signaling that causes NOS2 overexpression. Hepatotoxicity is restricted to female mice, suggesting that sex-specific effects of defective autophagy may underlie the increased susceptibility of females to IFNγ-mediated immune diseases.

Keyphrases

oxidative stress
cell death
endoplasmic reticulum stress
dendritic cells
signaling pathway
induced apoptosis
high fat diet induced
immune response
cell proliferation
type diabetes
nitric oxide synthase
drug induced
metabolic syndrome
nitric oxide