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Repression of PUM1-mediated mRNA decay activates translesion synthesis after DNA damage.

Toshimichi YamadaXiaoning SunNobuyoshi Akimitsu
Published in: Molecular & cellular oncology (2020)
Biological roles of Pumilio1 (PUM1) in ubiquitous cells remain unclear. Here we identify 48 degrading target mRNAs by combined analysis of transcriptome-wide mRNA stabilities and the binding of mRNAs. Further analysis revealed that cells respond to DNA damage by inhibiting PUM1-mediated mRNA decay to activate translesion synthesis (46/50).
Keyphrases
  • dna damage
  • induced apoptosis
  • oxidative stress
  • cell cycle arrest
  • binding protein
  • signaling pathway
  • dna repair
  • single cell
  • endoplasmic reticulum stress
  • cell death
  • genome wide
  • data analysis