Celecoxib alleviates nociceptor sensitization mediated by interleukin-1beta-primed annulus fibrosus cells.

Junxuan MaSurya HäneJanick EglaufJudith PfannkucheAstrid SoubrierZhen LiMarianna Peroglio Sven Hoppe Lorin M Benneker Gernot Michael Lang Sebastian WanglerMauro AliniLaura B CreemersSybille Grad Sonja Häckel

Published in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2023)

Cxb can inhibit PGE-2 production in hAFCs in an IL-1β-induced pro-inflammatory in vitro environment. The cxb applied to the hAFCs also reduces the sensitization of DRG nociceptors that are stimulated by the hAFCs CM.

Keyphrases

induced apoptosis
cell cycle arrest
diabetic rats
high glucose
aortic valve
drug induced
oxidative stress
signaling pathway
mouse model
cell proliferation