BLTR1 Is Decreased in Steroid Resistant Pro-Inflammatory CD28nullCD8+ T Lymphocytes in Patients with COPD-The Spillover Hypothesis Explained?

Greg HodgeHubertus JersmannMark HolmesPatrick AsareEugene RoscioliPaul N ReynoldsSandra Hodge

Published in: Biology (2023)

Loss of BLTR1 is associated with an increased inflammatory potential of CD28nullCD8+ T cells and may allow these pro-inflammatory steroid-resistant cells to migrate to peripheral blood. Treatment strategies that upregulate BLTR1 may reduce systemic inflammation and associated co-morbidity in patients with COPD.

Keyphrases

peripheral blood
chronic obstructive pulmonary disease
lung function
induced apoptosis
cell cycle arrest
oxidative stress
nk cells
cell death
risk assessment
human health
pi k akt