Anti-malarial Drugs Reduce Vascular Smooth Muscle Cell Proliferation via Activation of AMPK and Inhibition of Smad3 Signaling.
Heejung LeeJung-Hwa HanSujin KimSuji KimDu Hyong ChoChang-Hoon WooPublished in: Journal of lipid and atherosclerosis (2019)
The results demonstrated that CQ and HCQ inhibit cell proliferation and cell cycle progression in VSMCs via the AMPK-dependent signaling pathway. Carotid artery ligation-induced intima thickness was reduced in mouse arteries treated with CQ or HCQ, suggesting a role for antimalarial drugs in treating atherosclerosis and restenosis.
Keyphrases
- cell cycle
- cell proliferation
- smooth muscle
- pi k akt
- signaling pathway
- epithelial mesenchymal transition
- skeletal muscle
- drug induced
- plasmodium falciparum
- high glucose
- cardiovascular disease
- diabetic rats
- protein kinase
- optical coherence tomography
- transforming growth factor
- vascular smooth muscle cells
- type diabetes
- blood flow
- endoplasmic reticulum stress