Feline adipose tissue-derived mesenchymal stem cells pretreated with IFN-γ enhance immunomodulatory effects through the PGE₂ pathway.

Seol Gi Park Ju-Hyun An Qiang Li Hyung-Kyu Chae Su-Min Park Jeong Hwa Lee Jin Ok Ahn Woo-Jin Song Hwa Young Youn

Published in: Journal of veterinary science (2021)

IFN-γ pretreatment improves the immune regulatory profile of fAT-MSCs mainly via the secretion of PGE₂, which induces macrophage polarization and increases regulatory T-cell numbers.

Keyphrases

adipose tissue
dendritic cells
immune response
transcription factor
mesenchymal stem cells
high fat diet
type diabetes
metabolic syndrome