A Consecutive C-H Functionalization Triggered by Oxidation of Active sp3 C-H Bonds: Construction of 3,4-Dihydroquinoline-3-one Derivatives.

We report a consecutive C-H functionalization that constructs 3,4-dihydroquinoline-3-one derivatives in high yields. This reaction is triggered by oxidation of active sp3 C-H bonds of glycines and N-benzylanilines. In this radical mediated transformation, four sp3 C-H bonds are functionalized efficiently, together with construction of one heterocyclic ring with a quaternary carbon center.