Cross validated serum small extracellular vesicle microRNAs for the detection of oropharyngeal squamous cell carcinoma.

G C MayneC M WoodsN DharmawardanaT WangS KrishnanJ C HodgeA ForemanS BoaseA S CarneyE A W SigstonD I WatsonE H OoiDamian James Hussey

Published in: Journal of translational medicine (2020)

We developed a novel method, StaVarSel, that was able to identify a panel of miRNAs, present in small extracellular vesicles derived from blood serum, that robustly cross validated as a biomarker for the detection of HPV + OPSCC. This approach could be used to derive diagnostic biomarkers of other head and neck cancers.

Keyphrases

squamous cell carcinoma
loop mediated isothermal amplification
real time pcr
label free
high grade
sensitive detection