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The Value of Tumor Infiltrating Lymphocytes (TIL) for Predicting the Response to Neoadjuvant Chemotherapy (NAC) in Breast Cancer according to the Molecular Subtypes.

Ionut Flaviu FaurAmadeus DobrescuAdelina Ioana ClimPaul PascaCatalin Prodan-BarbulescuBogdan Daniel GherleCristi TartaAlexandru IsaicDan BrebuCiprian DutaBogdan TotoliciGabriel Lazar
Published in: Biomedicines (2023)
This study reveals the role of TIL as a predictive biomarker in breast cancer not only for the well-established TNBC (triple negative breast cancer) and HER2+ (Her2 overexpressed) subtypes but also in Luminal A and B molecular subtypes. In this scenario, the evaluation of sTIL as a novel predictive and therapy-predicting factor should become a routinely performed analysis that could guide clinicians when choosing the most appropriate therapy.
Keyphrases
  • neoadjuvant chemotherapy
  • locally advanced
  • lymph node
  • transcription factor
  • sentinel lymph node
  • palliative care
  • stem cells
  • squamous cell carcinoma
  • radiation therapy
  • rectal cancer
  • early stage
  • young adults