The Wnt-specific astacin proteinase HAS-7 restricts head organizer formation in Hydra.

Berenice ZieglerIrene YiallourosBenjamin TrageserSumit KumarMoritz MerckerSvenja KlingMaike FathUwe WarnkenMartina SchnölzerThomas W HolsteinMarkus HartlAnna Marciniak-CzochraJörg StetefeldWalter StöckerSuat Özbek

Published in: BMC biology (2021)

We show the astacin family protease HAS-7 maintains a single head organizer through proteolysis of HyWnt3. Our data suggest a negative regulatory function of Wnt processing astacin proteinases in the global patterning of the oral-aboral axis in Hydra.

Keyphrases

cell proliferation
stem cells
optic nerve
transcription factor
big data