The extracellular matrix molecules versican and hyaluronan in urethral and vaginal tissues in stress urinary incontinence.
Ingrid A HartenStephen P EvankoChong H ChoeEugene W LeeBhavin N PatelMarika BogdaniThomas N WightUna J LeePublished in: Neurourology and urodynamics (2021)
Reduction of Vcan-degrading enzymes and HA synthases at day 4 postsurgery indicates a potential delay in ECM turnover associated with SUI. Abundant Vcan is associated with inflammation and elastin fiber network disruption, warranting further investigation to determine its role in SUI pathogenesis.