Roles of ghrelin, hepcidin and HIF-2α in iron metabolism in iron deficiency anemia.

Esra Rizaogullari GuzelNihan Cansel SarkayaAyşegul Ugur KurtogluVolkan KarakusErdal Kurtoglu

Published in: Irish journal of medical science (2024)

The study suggests that the low hepcidin levels in IDA patients enhance iron absorption. The lack of significant HIF-2α level differences may be due to the absence of chronic hypoxia in current hemoglobin levels of IDA patients. Moreover, the low ghrelin levels in patients and the correlations between ghrelin, hepcidin, and HIF-2α in both groups indicate their involvement in iron metabolism.

Keyphrases

iron deficiency
end stage renal disease
chronic kidney disease
ejection fraction
newly diagnosed
endothelial cells
peritoneal dialysis
prognostic factors
patient reported outcomes