Does Systemic Methotrexate Therapy Induce Azole Resistance among Endogenous Candida Strains?

Dawid ŻyrekJoanna NowickaMagdalena PajączkowskaEwa Morgiel

Published in: Antibiotics (Basel, Switzerland) (2021)

Despite slightly higher incidence of fluconazole-resistant strains among patients on systemic methotrexate therapy, we found no solid evidence to support the hypothesis that methotrexate induces resistance to azoles among endogenous Candida strains in patients with rheumatological diseases.

Keyphrases

candida albicans
escherichia coli
high dose
biofilm formation
risk factors
stem cells
staphylococcus aureus
cystic fibrosis
mesenchymal stem cells
bone marrow
drug induced
smoking cessation