Construction of an iridium(iii)-complex-loaded MOF nanoplatform mediated with a dual-responsive polycationic polymer for photodynamic therapy and cell imaging.
Yongxin ZhangHao FuShuai ChenBingqing LiuWenfang SunHui GaoPublished in: Chemical communications (Cambridge, England) (2019)
A multifunctional photodynamic therapy (PDT) nanoplatform, characterized by red-shifted absorption and emission, was fabricated using an UiO-66-based metal-organic framework (MOF), a biscyclometalated iridium(iii) complex, and a pH/ROS-responsive polycationic polymer. Noticeably, this promising nanoplatform exhibited good biocompatibility in the dark and produced abundant ROS upon light irradiation, which could achieve apparent endo/lysosome escape and kill cancer cells effectively.
Keyphrases
- metal organic framework
- photodynamic therapy
- cancer therapy
- fluorescence imaging
- drug delivery
- cell death
- dna damage
- reactive oxygen species
- high resolution
- single cell
- cell therapy
- magnetic resonance imaging
- bone marrow
- magnetic resonance
- living cells
- oxidative stress
- diffusion weighted imaging
- radiation induced
- drug release
- single molecule