Microdissecting the Hypoxia Landscape in Colon Cancer Reveals Three Distinct Subtypes and Their Potential Mechanism to Facilitate the Development of Cancer.
Pingfei TangYueming WuChaojun ZhuQingyuan LiSi-de LiuPublished in: Journal of oncology (2023)
In our study, we discovered three hypoxia clusters which correlate with the clinical outcome and the tumor immune microenvironment in CC. Based on the hypoxia cluster and HRDEGs, we constructed a reliable HRI signature that could accurately predict the prognosis and immunotherapeutic responsiveness in CC patients and discovered four key genes that could affect tumor cell viability and apoptosis.
Keyphrases
- end stage renal disease
- endothelial cells
- chronic kidney disease
- newly diagnosed
- ejection fraction
- oxidative stress
- stem cells
- peritoneal dialysis
- endoplasmic reticulum stress
- genome wide
- wastewater treatment
- cell death
- squamous cell carcinoma
- cell cycle arrest
- single cell
- patient reported outcomes
- cell proliferation