Melatonin attenuates scopolamine-induced cognitive dysfunction through SIRT1/IRE1α/XBP1 pathway.

Xiao-Qi LiuShun HuangJia-Yi ZhengCan WanTian HuYe-Feng CaiQi WangShi-Jie Zhang

Published in: CNS neuroscience & therapeutics (2024)

These results indicated that melatonin could ameliorate SCOP-induced cognitive dysfunction through the SIRT1/IRE1α/XBP1 pathway. SIRT1 might be the critical target of melatonin in the treatment of dementia.

Keyphrases

oxidative stress
diabetic rats
high glucose
ischemia reperfusion injury
endoplasmic reticulum stress
drug induced
endothelial cells
cognitive impairment
replacement therapy