Tibial post fracture pain is reduced in kinin receptors deficient mice and blunted by kinin receptor antagonists.

Vincent MinvilleLionel MouledousAcil JaafarRéjean CoutureAnne BrouchetBernard FrancesIvan TackJean-Pierre Girolami

Published in: Journal of translational medicine (2019)

It is suggested that B1R and B2R activation contributes significantly to tibial fracture pain through COX. Hence, B1R and B2R antagonists appear potential therapeutic agents to manage post fracture pain.

Keyphrases

chronic pain
pain management
neuropathic pain
total knee arthroplasty
hip fracture
spinal cord injury
anterior cruciate ligament reconstruction