The role of anti-thymocyte globulin in allogeneic stem cell transplantation (HSCT) from HLA-matched unrelated donors (MUD) for secondary AML in remission: a study from the ALWP /EBMT.
Arnon NaglerMyriam LabopinNicolaus M KrögerThomas SchroederTobias Gedde-DahlMatthias EderGeorg-Nikolaus FrankeIgor Wolfgang BlauUrpu SalmenniemiGerard SocièJohannes ScheteligMatthias StelljesFabio CiceriFlorent MalardPublished in: Bone marrow transplantation (2023)
We compared outcomes, of 1609 patients with secondary acute myeloid leukemia (sAML) undergoing allogeneic transplantation (HSCT) in first complete remission (CR1) from matched unrelated donors (MUD) from 2010 to 2021, receiving or not receiving anti-thymocyte globulin (ATG) (ATG-1308, no ATG-301). Median age was 60.9 (range, 18.5-77.8) and 61.1 (range, 21.8-75.7) years, (p = 0.3). Graft versus host disease (GVHD) prophylaxis was cyclosporin-A with methotrexate (41%) or mycophenolate mofetil (38.2%), without significant differences between groups. Day 28, engraftment (ANC > 0.5 × 10 9 /L) was 92.3% vs 95.3% (p = 0.17), respectively. On multivariate analysis, ATG was associated with lower incidence of grade II-IV and grade III-IV acute GVHD (p = 0.002 and p = 0.015), total and extensive chronic GVHD (p = 0.008 and p < 0.0001), and relapse incidence (RI) (p = 0.039), while non-relapse mortality (NRM) did not differ (p = 0.51). Overall survival (OS), and GVHD-free, relapse-free survival (GRFS) were significantly higher in the ATG vs no ATG group, HR = 0.76 (95% CI 0.61-0.95, p = 0.014) and HR = 0.68 (95% CI 0.57-0.8, p < 0.0001), with a tendency for better leukemia-free survival (LFS), HR = 0.82 (95% CI 0.67-1, p = 0.051). The main causes of death were the original disease, infection, and GVHD. In conclusion, ATG reduces GVHD and improves LFS, OS, and GRFS in sAML patients without increasing the RI, despite sAML being a high-risk disease.
Keyphrases
- free survival
- stem cell transplantation
- allogeneic hematopoietic stem cell transplantation
- acute myeloid leukemia
- high dose
- hematopoietic stem cell
- risk factors
- bone marrow
- acute lymphoblastic leukemia
- newly diagnosed
- ejection fraction
- stem cells
- low dose
- cardiovascular disease
- metabolic syndrome
- drug induced
- liver failure
- skeletal muscle
- mesenchymal stem cells
- hepatitis b virus
- weight loss
- kidney transplantation