The role of fibroblast growth factor 1 and 2 on the pathological behavior of valve interstitial cells in a three-dimensional mechanically-conditioned model.

Ngoc Thien LamIshita TandonKartik Balachandran

Published in: Journal of biological engineering (2019)

Overall, these results suggested that targeting FGFR1 receptor signaling may represent a possible therapeutic strategy for preventing heart valve disease progression.

Keyphrases

aortic valve
mitral valve
induced apoptosis
aortic stenosis
cell cycle arrest
heart failure
transcatheter aortic valve replacement
atrial fibrillation
cancer therapy
endoplasmic reticulum stress
ejection fraction
oxidative stress
cell proliferation
drug delivery