Mutational Profile of Metastatic Breast Cancers: A Retrospective Analysis.

Celine LefebvreThomas BachelotThomas FilleronMarion PedreroMario CamponeJean-Charles SoriaChristophe MassardChristelle LévyMonica ArnedosMagali Lacroix-TrikiJulie GarrabeyYannick BoursinMarc DelogerYu FuFrédéric CommoVéronique ScottLudovic Lacroix Maria Vittoria DieciMaud KamalVéronique DiérasAnthony GonçalvesJean-Marc FerrerroGilles RomieuLaurence VanlemmensMarie-Ange Mouret ReynierJean-Christophe ThéryFanny Le DuSéverine GuiuFlorence DalencGilles ClapissonHervé BonnefoiMarta JimenezChristophe Le TourneauFabrice André

Published in: PLoS medicine (2016)

This work reports the results of the analysis of the first large-scale study on mutation profiles of mBC. This study revealed genomic alterations and mutational signatures involved in the resistance to therapies, including actionable mutations.

Keyphrases

squamous cell carcinoma
small cell lung cancer
emergency department
gene expression
copy number