The Genetic Relationship Between Alcohol Consumption and Aspects of Problem Drinking in an Ascertained Sample.
Emma C JohnsonCeline L St PierreJacquelyn L MeyersFazil AlievVivia V McCutcheonDongbing LaiDanielle M DickAlison M GoateJohn R KramerSamuel KupermanJohn I NurnbergerMarc A SchuckitBernice PorjeszHoward J EdenbergKathleen K BucholzArpana AgrawalPublished in: Alcoholism, clinical and experimental research (2019)
Genetic propensity for typical alcohol consumption was associated with alcohol use and was also associated with 4 of the additional 5 outcomes, though the variance explained in this sample was modest. Future GWAS that focus on the multifaceted nature of AUD, which goes beyond consumption, might reveal additional information regarding the polygenic underpinnings of problem drinking.