Mesoporous silica with precisely controlled pores reduces food efficiency and suppresses weight gain in mice.
Mia RindeNatalia KupferschmidtMuhammad Naeem IqbalGhislaine Robert-NicoudEric V JohnstonMaria LindgrenTore BengtssonPublished in: Nanomedicine (London, England) (2020)
Aim: Obesity is a risk factor for cardiovascular disease and diabetes. We aimed to elucidate the effects of distinct mesoporous silica particles (MSPs) supplemented in food on metabolic parameters in obesity. Materials & methods: MSPs with precisely controlled pore size were synthesized, characterized and compared with a control in a C57Bl/6 mouse diet-induced obesity model, studying weight, adiposity, metabolic regulation and food efficiency. Results: The most effective MSPs reduced adipose tissue formation to 6.5 ± 0.5 g compared with 9.4 ± 1.2 g, leptin levels nearly halved from 32.8 ± 7.4 to 16.9 ± 1.9 ng/ml and a 33% reduction of food efficiency. Control MSP showed no effects. Conclusion: Results demonstrate potential of distinct MSPs to improve metabolic risk factors. Further studies investigating mechanism of action and confirming human safety are needed.
Keyphrases
- weight gain
- insulin resistance
- body mass index
- weight loss
- birth weight
- high fat diet induced
- cardiovascular disease
- adipose tissue
- type diabetes
- human health
- risk factors
- metabolic syndrome
- endothelial cells
- high fat diet
- risk assessment
- signaling pathway
- physical activity
- coronary artery disease
- climate change
- cardiovascular risk factors
- plasmodium falciparum
- wild type
- oxide nanoparticles