Deficiency of Nrf2 exacerbates white matter damage and microglia/macrophage levels in a mouse model of vascular cognitive impairment.

Emma SigfridssonMartina MarangoniGiles E HardinghamKaren HorsburghJill H Fowler

Published in: Journal of neuroinflammation (2020)

The results demonstrate that the absence of Nrf2 exacerbates white matter pathology and microgliosis following cerebral hypoperfusion but does not affect behavioural impairment.

Keyphrases

white matter
cognitive impairment
oxidative stress
mouse model
multiple sclerosis
subarachnoid hemorrhage
inflammatory response
adipose tissue
spinal cord