Characteristics and outcomes of gemcitabine-associated pulmonary hypertension.
Pierre MouillotNicolas FavroltCharles KhouriAurélie GrandvuilleminMarie-Camille ChaumaisDéborah SchenesseAndrei SeferianXavier JaisLaurent SavaleGuillaume BeltramoOlivier SitbonJean-Luc CracowskiMarc HumbertMarjolaine GeorgesPhilippe BonniaudI David MontaniPublished in: ERJ open research (2024)
Both clinical cases and pharmacovigilance data substantiate a significant association between gemcitabine use and the onset or worsening of precapillary PH. The observed improvement following the discontinuation of treatment underscores the importance of PH screening in gemcitabine-exposed patients experiencing unexplained dyspnoea.
Keyphrases
- pulmonary hypertension
- end stage renal disease
- locally advanced
- ejection fraction
- chronic kidney disease
- newly diagnosed
- peritoneal dialysis
- pulmonary artery
- type diabetes
- pulmonary arterial hypertension
- emergency department
- skeletal muscle
- metabolic syndrome
- coronary artery
- adverse drug
- artificial intelligence
- rectal cancer