Severe Hepatopathy in National Wilms Tumor Studies 3-5: Prevalence, Clinical Features, and Outcomes After Reintroduction of Chemotherapy.
Natanja OosteromSaskia L M GooskensLindsay A RenfroElizabeth J PerlmanMarry M van den Heuvel-EibrinkThomas E HamiltonDaniel M GreenPaul E GrundyNajat C DawJames I GellerJeffrey S DomeConrad V FernandezElizabeth A MullenPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
The incidence of SH on NWTS 3-5 was low; many had associated severe thrombocytopenia. Careful reintroduction of chemotherapy appeared to be feasible for the majority of patients who developed severe chemotherapy- and/or radiotherapy-induced liver toxicity.